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Pre-Clinical Strategies to Overcome Drug-Resistant Multiple Myeloma: Predictive Transcriptomics and Targeting the Myeloma Epigenome
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Pre-Clinical Strategies to Overcome Drug-Resistant Multiple Myeloma: Predictive Transcriptomics and Targeting the Myeloma Epigenome. |
| 개인저자 | Harding, Taylor Stiver. |
| 단체저자명 | University of Minnesota. Biological Science. |
| 발행사항 | [S.l.]: University of Minnesota., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 179 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438031364 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Includes supplementary digital materials. Adviser: Brian Van Ness. |
| 요약 | Multiple myeloma remains an incurable hematological malignancy due to the failure of standard-of-care therapies to broadly target a genetically heterogeneous disease and an inability overcome inevitable drug-resistant relapse. This dissertation |
| 요약 | First, our goal was to develop a gene expression signature that predicts response specific to proteasome inhibitor (PI) treatment in MM. Using a well-characterized panel of human myeloma cell lines (HMCLs) representing the biological and genetic |
| 요약 | Epigenetic abnormalities are abundantly present in multiple myeloma and accumulating evidence suggests that the histone methyltransferase EZH2 is aberrantly active in MM. We tested the efficacy of EZH2 specific inhibitors in a large panel of hum |
| 일반주제명 | Genetics. Molecular biology. Bioinformatics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
