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Manipulating Exosome Signaling to Inhibit Tumor Metastasis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Manipulating Exosome Signaling to Inhibit Tumor Metastasis. |
| 개인저자 | Plebanek, Michael Paul. |
| 단체저자명 | Northwestern University. Life Sciences. |
| 발행사항 | [S.l.]: Northwestern University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 161 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438116207 |
| 학위논문주기 | Thesis (Ph.D.)--Northwestern University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisers: Colby S. Thaxton |
| 요약 | Over the past decade significant advancements have been made across the field of cancer biology resulting in transformative new therapies. Despite these advancements, treatments for metastatic cancer remain relatively ineffective. Metastasis is |
| 요약 | In this project, we were first interested in understanding the effects of exosomes released from non-metastatic cancer cells. It is well established that exosomes from aggressive cancer cells promote metastasis, but the functions of non-aggressi |
| 요약 | Additionally, due to the metastasis promoting functions of tumor exosomes, we were interested in developing a technology to specifically inhibit the uptake of cancer exosomes by target cells. Exosome uptake is dependent on cholesterol-rich lipid |
| 요약 | The development of HDL NPs led us to test their efficacy as a cancer therapeutic in a wide array of applications. We discovered that HDL NPs can function to inhibit metastasis independent of inhibiting exosome uptake, as well. Myeloid-derived su |
| 일반주제명 | Biology. Oncology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
