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Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease. |
| 개인저자 | Kam, Chen Yuan. |
| 단체저자명 | Northwestern University. Life Sciences. |
| 발행사항 | [S.l.]: Northwestern University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 172 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438116153 |
| 학위논문주기 | Thesis (Ph.D.)--Northwestern University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Kathleen J. Green. |
| 요약 | Desmoplakin (DP) is a component of desmosomes, critical adhesive complexes found in cardiac intercalated discs. DP is often mutated in arrhythmogenic cardiomyopathy (AC), an inherited disorder that is a frequent cause of sudden cardiac death. Th |
| 요약 | Gap junctions, comprised of connexin (Cx) molecules are specialized intercellular channels that are indispensable in the myocardium where they coordinate the propagation of electrical signals between cardiomyocytes. Here, we elucidate a mechanis |
| 요약 | Loss of DP was also found to perturb the junctional localization and activation of RhoA GTPase signaling in cardiomyocytes. The small GTPase RhoA plays a fundamental role in regulating actomyosin contractility via its various downstream effector |
| 요약 | Finally, we investigated Plakophilin-2 (PKP2), a desmosome component that is critical for DP expression and localization in cardiac cells, and its role in promoting fibrotic signaling pathways in cardiac cells. Loss of PKP2 led to the activation |
| 일반주제명 | Cellular biology. Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
