자료유형 | 학위논문 |
---|---|
서명/저자사항 | Characterization of Type I Collagen and Osteoblast Response to Mechanical Loading. |
개인저자 | Canelon, Silvia P. |
단체저자명 | Purdue University. Biomedical Engineering. |
발행사항 | [S.l.]: Purdue University., 2018. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
형태사항 | 99 p. |
기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
ISBN | 9780438018761 |
학위논문주기 | Thesis (Ph.D.)--Purdue University, 2018. |
일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Joseph M. Wallace |
요약 | Bone is a composite material made up of an inorganic (hydroxyapatite mineral) phase, a proteinaceous organic phase, and water. Comprising 90% of bone's organic phase, type I collagen is the most abundant protein in the human body. Both hydroxyap |
요약 | Type I collagen in bone is synthesized by osteoblasts as a helical structure formed from three polypeptide chains of amino acids. These molecules are staggered into an array and the resulting collagen fibrils are stabilized by crosslinks. Enzyma |
요약 | Understanding how changes in bone properties on a cellular level transcend levels of bone hierarchy provides an opportunity to detect or diagnose bone disease before disease-related changes are expressed at the organ or tissue level. This disser |
일반주제명 | Biomedical engineering. Biomechanics. Biology. |
언어 | 영어 |
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