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Characterization of Type I Collagen and Osteoblast Response to Mechanical Loading

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서명/저자사항Characterization of Type I Collagen and Osteoblast Response to Mechanical Loading.
개인저자Canelon, Silvia P.
단체저자명Purdue University. Biomedical Engineering.
발행사항[S.l.]: Purdue University., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항99 p.
기본자료 저록Dissertation Abstracts International 79-10B(E).
Dissertation Abstract International
ISBN9780438018761
학위논문주기Thesis (Ph.D.)--Purdue University, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisers: Joseph M. Wallace
요약Bone is a composite material made up of an inorganic (hydroxyapatite mineral) phase, a proteinaceous organic phase, and water. Comprising 90% of bone's organic phase, type I collagen is the most abundant protein in the human body. Both hydroxyap
요약Type I collagen in bone is synthesized by osteoblasts as a helical structure formed from three polypeptide chains of amino acids. These molecules are staggered into an array and the resulting collagen fibrils are stabilized by crosslinks. Enzyma
요약Understanding how changes in bone properties on a cellular level transcend levels of bone hierarchy provides an opportunity to detect or diagnose bone disease before disease-related changes are expressed at the organ or tissue level. This disser
일반주제명Biomedical engineering.
Biomechanics.
Biology.
언어영어
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