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Isolation and Characterization of HIV-1 Neutralizing Antibodies from Infants
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Isolation and Characterization of HIV-1 Neutralizing Antibodies from Infants. |
| 개인저자 | Simonich, Cassandra. |
| 단체저자명 | University of Washington. Molecular and Cellular Biology. |
| 발행사항 | [S.l.]: University of Washington., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 198 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438173668 |
| 학위논문주기 | Thesis (Ph.D.)--University of Washington, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Julie M. Overbaugh. |
| 요약 | Developing a protective HIV vaccine remains a key goal of prevention efforts. Broadly neutralizing antibodies (bnAbs) that recognize diverse circulating strains of HIV are thought to be an important component of a protective vaccine but elicitin |
| 요약 | First, we isolated nAbs contributing to a broad plasma response at one year post-infection from infant BF520. We observed that polyclonal nAbs with low SHM contribute to plasma neutralizing activity. Additionally, we isolated one infant-derived |
| 요약 | Next, we characterized the ontogeny of the infant-derived bnAb by reconstructing the naive progenitor and developmental intermediates. We observed that the naive antibody recognizes HIV Env, which contrasts with precursors of many adult bnAbs. T |
| 요약 | Finally, we isolated and characterized nAbs contributing to plasma breadth at two years post-infection from infant BG505. This infant is of particular interest to the HIV field because the Env of the transmitted virus from BG505 has been extensi |
| 요약 | These studies showed that infant antibodies have features distinct from adult antibodies, including several that may be amenable to better vaccine responses. This work represents the first isolation and characterization of a HIV-bnAb from an inf |
| 일반주제명 | Virology. Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
