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Interplay of Host and Pathogen Factors Determines Immunity and Clinical Outcome Following Campylobacter jejuni Infection in Mice
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Interplay of Host and Pathogen Factors Determines Immunity and Clinical Outcome Following Campylobacter jejuni Infection in Mice. |
| 개인저자 | Brudvig, Jean Marie. |
| 단체저자명 | Michigan State University. Comparative Medicine and Integrative Biology - Doctor of Philosophy. |
| 발행사항 | [S.l.]: Michigan State University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 253 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-09B(E). Dissertation Abstract International |
| ISBN | 9780355867060 |
| 학위논문주기 | Thesis (Ph.D.)--Michigan State University, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B.
Adviser: Linda S. Mansfield. |
| 이용제한사항 | This item is not available from ProQuest Dissertations & Theses. |
| 요약 | Campylobacter jejuni is a common cause of bacterial enteritis worldwide, and is associated with the post-infectious neuropathy Guillain-Barre syndrome (GBS). The currently accepted pathogenesis of C. jejuni-associated GBS involves generation of |
| 요약 | The model system was developed to exploit both C. jejuni strain differences and immunogenetic biases reported for C57BL/6 and BALB/c mice. C. jejuni strains associated with colitis ( C. jejuni 11168) and GBS (C. jejuni 260.94) were used in combi |
| 요약 | BALB/c wild-type and IL-10-/- mice infected with C. jejuni 260.94 were first assessed as a potential GBS model. C57BL/6 IL-10-/- mice infected with C. jejuni 260.94 were previously shown to mount Th2-mediated immunity and produce anti-gangliosi |
| 요약 | The second in vivo study was designed to further explore these contrasting immune responses. Both C57BL/6 IL-10-/- and BALB/c IL-10-/- mice were orally infected with colitogenic C. jejuni 11168 or GBS-associated C. jejuni 260.94. Immunity and d |
| 요약 | Results of the current studies demonstrate that immunity and disease outcome following C. jejuni infection depend upon the characteristics of both the infecting C. jejuni strain and host genetic background, and implicate DCs as early contributor |
| 일반주제명 | Immunology. Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
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