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Staphylococcus Aureus alpha-toxin Damages the Tissue Microenvironment during Skin and Soft Tissue Infection
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Staphylococcus Aureus alpha-toxin Damages the Tissue Microenvironment during Skin and Soft Tissue Infection. |
| 개인저자 | Sampedro, Georgia Rafaella. |
| 단체저자명 | The University of Chicago. Microbiology. |
| 발행사항 | [S.l.]: The University of Chicago., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 140 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438088344 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Chicago, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Juliane Bubeck Wardenburg. |
| 요약 | Staphylococcus aureus is a pathobiont that can cause a range of mild to life-threatening infection in otherwise healthy individuals. While S. aureus disease has a broad tissue tropism, the most common site for both colonization and infection is |
| 요약 | To investigate whether there is a mechanistic link between alpha-toxin expression and the severity of S. aureus reinfection patterns, we developed a mouse model of recurrent S. aureus SSTI mouse model. Using an isogenic Hla mutant in this model |
| 요약 | Probing into mechanism, we identified Hla-mediated injury to cutaneous resident innate-like T cells as the cellular gatekeeper of S. aureus SSTI infection outcomes. alpha-Toxin kills both neighboring and distant epidermal T cells adjacent to th |
| 일반주제명 | Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
