상세정보
Export to Refworks부가기능
Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function. |
| 개인저자 | Shoucri, Bassem Merit. |
| 단체저자명 | University of California, Irvine. Biological Sciences. |
| 발행사항 | [S.l.]: University of California, Irvine., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 191 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438296176 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Irvine, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Includes supplementary digital materials. Adviser: Bruce Blumberg. |
| 요약 | The obesity epidemic has reached unsustainable proportions and threatens to bankrupt the American healthcare system. While physicians continue to prescribe diet and exercise as a panacea for obesity, mounting evidence shows that the majority of |
| 요약 | Mounting evidence implicates early-life exposure to industrial chemicals---of which there are tens of thousands---as an overlooked contributor to the obesity epidemic. Of particular concern are a subset of at least 1,000 chemicals, termed endocr |
| 요약 | Our lab identified and characterized the archetypal obesogen, tributyltin (TBT), which acts through two nuclear receptors, peroxisome proliferator-activated receptor gamma and retinoid X receptor (RXR), to promote the development of fat tissue. |
| 요약 | The work described in this dissertation employs the in vitro MSC adipogenesis model to further explore the molecular mechanisms through which TBT alters the fate and function of developing stem cells. In Chapter 1, we investigate how TBT influ |
| 일반주제명 | Developmental biology. Endocrinology. Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
