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Induction of Antibodies to HIV-1 Envelope Using Simian Adenovirus Vaccines
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Induction of Antibodies to HIV-1 Envelope Using Simian Adenovirus Vaccines. |
| 개인저자 | Emmer, Kristel Lucie. |
| 단체저자명 | University of Pennsylvania. Cell and Molecular Biology. |
| 발행사항 | [S.l.]: University of Pennsylvania., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 143 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-10B(E). Dissertation Abstract International |
| ISBN | 9780438036123 |
| 학위논문주기 | Thesis (Ph.D.)--University of Pennsylvania, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Hildegund C. Ertl. |
| 요약 | Human immunodeficiency virus type 1 (HIV-1) has infected 76 million people since the beginning of the epidemic. The first evidence that an HIV-1 vaccine could prevent infection in humans was provided in the RV144 vaccine efficacy trial. RV144 de |
| 요약 | Several approaches can be employed to improve upon vaccination strategies: heterologous prime-boost regimens, immunogen design, and alternative adjuvants. To enhance Env-specific antibodies, I tested simian-derived adenovirus (SAdV) vectors expr |
| 요약 | It has been suggested that a vaccine designed to elicit greater V2-specific antibody responses than that seen in the RV144 trial may be more effective at preventing HIV-1 infection. The variable 1 and 2 (V1/V2) region of Env has been grafted ont |
| 요약 | In the third study, I tested calcium phosphate (CaP) as an adjuvant to a recombinant Env protein compared to alum adjuvant. Alum, the most commonly used adjuvant, induces suboptimal immune responses. CaP has demonstrated preferential immune resp |
| 요약 | These studies demonstrate SAdV vectors as advantageous vaccine vector platforms and that novel immunogen design can improve HIV-1 vaccines. |
| 일반주제명 | Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
