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The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Signaling Pathways that Regulate the Proliferative and Neurogenic Capacity of Muller glia. |
| 개인저자 | Todd, Levi. |
| 단체저자명 | The Ohio State University. Neuroscience Graduate Studies Program. |
| 발행사항 | [S.l.]: The Ohio State University., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 178 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438097797 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Andrew Fischer. |
| 요약 | Eye diseases that result in blindness are often caused by the death of retinal neurons. Muller glia are the major glial support cells in the retina and possess the potential to reprogram into neurogenic progenitor cells. In the fish, Muller glia |
| 요약 | The first chapter focuses on how Hedgehog signaling stimulates Muller glia to reprogram into proliferating progenitors in the chick retina. We show that the Hedgehog-pathway components are up-regulated in damaged retinas when MGPCs are known to |
| 요약 | The second chapter examines how Jak/Stat signaling impacts the regenerative capacity of the avian retina. We find that Jak/Stat signaling is rapidly activated in Muller glia in response to retinal damage. We also show that inhibition of the Jak/ |
| 요약 | The third chapter analyzes how Retinoic acid (RA)-signaling regulates the proliferative and neurogenic potential of avian Muller glia. We find that the RA-component CRABP is specifically up-regulated by Muller glia in response to retinal injury. |
| 요약 | Collectively, the work described in this dissertation represents significant advances in understanding the mechanisms underlying retinal regeneration in the avian retina. Each chapter describes novel data regarding the signaling pathways that re |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
