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Positron Emission Tomography Radiochemistry: Improved Methodology and a Novel PET Imaging Agent for the Dopamine D3 Receptor
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Positron Emission Tomography Radiochemistry: Improved Methodology and a Novel PET Imaging Agent for the Dopamine D3 Receptor. |
| 개인저자 | Stewart, Megan N. |
| 단체저자명 | University of Michigan. Medicinal Chemistry. |
| 발행사항 | [S.l.]: University of Michigan., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 462 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438125841 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Peter J. Scott. |
| 요약 | Positron Emission Tomography (PET) imaging is a powerful non-invasive imaging modality used to quantify biochemical processes in vivo. The work described in this thesis encompasses two aspects of PET radiochemistry: (1) the development of new ch |
| 요약 | (1) As a way to simplify FDA mandated quality control and residual solvent analysis prior to the release of PET radiopharmaceuticals we sought to apply the principles of green chemistry to 18F-radiochemistry. Green radiochemistry in late-stage s |
| 요약 | (2) Dopamine is a monoamine neurotransmitter in the Central Nervous System (CNS), and its signaling is mediated by pre-synaptic and post-synaptic dopamine receptors. These are D1-like (D1 and D5) and D2-like (D2, D3, D4) receptors, which are G p |
| 요약 | The synthesis and initial evaluation of a series of new carbon-11 and fluorine-18 PET radioligands for the D3 receptor is described. These radioligands are based on known ligands with good selectivity for the D3 receptor (pramipexole and BP897). |
| 일반주제명 | Medical imaging. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
