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Fasting Protects against Proteostasis Defects Induced by Hypoxia
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Fasting Protects against Proteostasis Defects Induced by Hypoxia. |
| 개인저자 | Iranon, Nicole Nalani. |
| 단체저자명 | University of Washington. Molecular and Cellular Biology. |
| 발행사항 | [S.l.]: University of Washington., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 153 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438175433 |
| 학위논문주기 | Thesis (Ph.D.)--University of Washington, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Dana Miller. |
| 요약 | When blood flow to various parts of the body becomes restricted, those tissues suffer from a lack of oxygen, a condition called hypoxia. Hypoxia can impair essential physiological processes and cause cellular damage and death, such as is observe |
| 요약 | I show that nutritional cues regulate the effect of hypoxia on proteostasis and that both the insulin/IGF-1 signaling (IIS) pathway and AMP-activated protein kinase (AMPK) play roles in mediating the effects of hypoxia and nutrient deprivation o |
| 요약 | Furthermore, I found a role for AMPK in regulating the response to hypoxia that depends on the nutritional status of the animal. In fed conditions AMPK promotes protein aggregation, but without food AMPK is required for fasting-induced protectio |
| 일반주제명 | Biology. Pathology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
