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Enantioselective Total Syntheses of Akuammiline Alkaloids and Arynes as Building Blocks for Enantioenriched Products

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서명/저자사항Enantioselective Total Syntheses of Akuammiline Alkaloids and Arynes as Building Blocks for Enantioenriched Products.
개인저자Picazo, Elias.
단체저자명University of California, Los Angeles. Chemistry 0153.
발행사항[S.l.]: University of California, Los Angeles., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항564 p.
기본자료 저록Dissertation Abstracts International 79-10B(E).
Dissertation Abstract International
ISBN9780438037939
학위논문주기Thesis (Ph.D.)--University of California, Los Angeles, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Adviser: Neil K. Garg.
요약This dissertation features two projects concerning natural product synthesis and reaction development. The importance of natural product synthesis in chemistry and medicine cannot be overstated. In addition to providing a complex setting to test
요약Chapters One, Two, Three, and Four focus on an unusual variant of the Fischer indolization reaction and its application in the total synthesis of a particularly interesting class of indole alkaloids named the akuammilines. Specifically, Chapter
요약Chapters Two, Three, and Four describe enantioselective syntheses of various akuammiline alkaloids, in addition to several akuammiline alkaloid derivatives. Central to our approach was the development of modern variants of the classic Fischer in
요약Chapters Five describes an application of the distortion/interaction model to a variety of mono and disubstituted benzynes and substituted indolynes. Chapter Six is focused on the development of a facile method to synthesize stereodefined quater
일반주제명Organic chemistry.
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