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Cross-activating c-Met/beta1 Integrin Complex Drives Metastasis and Invasive Resistance in Cancer
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Cross-activating c-Met/beta1 Integrin Complex Drives Metastasis and Invasive Resistance in Cancer. |
| 개인저자 | Jahangiri, Arman. |
| 단체저자명 | University of California, San Francisco. Biomedical Sciences. |
| 발행사항 | [S.l.]: University of California, San Francisco., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 144 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438250314 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, San Francisco, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Joseph F. Costello |
| 요약 | The molecular underpinnings of invasion, a hallmark of cancer, have been defined in terms of individual mediators but crucial interactions between these mediators remain undefined. In xenograft models and patient specimens, we identified a c-Met |
| 요약 | Inducing c-Met/beta1 complex formation through an engineered inducible heterodimerization system promoted features crucial to overcoming stressors during metastases or antiangiogenic therapy: migration in the primary site, survival under hypoxia |
| 요약 | Complex formation promoted ligand-independent receptor activation, with integrin-linked kinase phosphorylating c-Met and crystallography revealing the c-Met/beta1 complex to maintain the high-affinity beta1 integrin conformation. Site-directed m |
| 일반주제명 | Oncology. Biochemistry. Cellular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
