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Innovative Microbial Outcomes in Randomized Control Trials

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서명/저자사항Innovative Microbial Outcomes in Randomized Control Trials.
개인저자Ray, Kathryn.
단체저자명University of California, San Francisco. Epidemiology and Translational Science.
발행사항[S.l.]: University of California, San Francisco., 2018.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2018.
형태사항76 p.
기본자료 저록Dissertation Abstracts International 79-12B(E).
Dissertation Abstract International
ISBN9780438250369
학위논문주기Thesis (Ph.D.)--University of California, San Francisco, 2018.
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Thomas M. Lietman.
요약Randomized Control Trials (RCTs) in infectious disease can use a clinical outcome or a microbiological surrogate outcome. While caregivers are more interested in the clinical outcome, the microbiological outcome may be far more sensitive. Here I
요약In chapter one, I design and analyze an experiment to compare community microbiome diversity estimates derived from 16s rRNA sequencing of 1) individually sequenced specimens versus 2) pooled specimens collected from a community. I then compare
요약The estimates of community level microbiome diversity from pooled samples correlated well with estimates from individual samples. Additionally, all pooled samples fell within the 95% limits of agreement. Pooling microbiome samples to estimate co
일반주제명Epidemiology.
Public health.
언어영어
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