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Tlr4-Activated Microglia Have Divergent Effects on Oligodendrocyte Lineage Cells
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Tlr4-Activated Microglia Have Divergent Effects on Oligodendrocyte Lineage Cells. |
| 개인저자 | Goldstein, Evan Zachary. |
| 단체저자명 | The Ohio State University. Neuroscience. |
| 발행사항 | [S.l.]: The Ohio State University., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 217 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438309722 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Dana McTigue. |
| 요약 | Myelin accelerates action potential conduction velocity and provides essential metabolic support for axons. Unfortunately, myelin and myelinating cells are often vulnerable to injury or disease, resulting in myelin damage, which in turn can lead |
| 요약 | Many factors produced by TLR4-activated microglia have no known effects on OL lineage cells. In chapter 3, colony stimulating factor 3 (CSF3) and interleukin 7 (IL-7) were identified as factors produced by TLR4-activated microglia that might con |
| 요약 | In chapter 4, an innate TLR4-induced iron chelation response was harnessed to sequester iron in a model of intraspinal iron accumulation. Because excess iron induces progressive neuronal and OL death, we hypothesized that intraspinal TLR4 activa |
| 일반주제명 | Medicine. Molecular biology. Biomedical engineering. Immunology. Neurosciences. Biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
