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Characterizing the Role of RCAN1-4 in Thyroid Cancer Growth and Metastasis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Characterizing the Role of RCAN1-4 in Thyroid Cancer Growth and Metastasis. |
| 개인저자 | Wang, Chaojie. |
| 단체저자명 | The Ohio State University. Biochemistry. |
| 발행사항 | [S.l.]: The Ohio State University., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 148 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438310117 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Matthew Ringel. |
| 요약 | Metastatic progression is the main cause of cancer-related deaths. Metastasis suppressors are proteins that inhibit metastatic progression without affecting primary tumor formation that are distinct from tumor suppressor genes. Loss of metastasi |
| 요약 | In this study, our goal is to characterize the role of RCAN1-4, the inducible RCAN1 isoform in tumor growth and metastasis using thyroid cancer models. RCAN1-4 knockdown or inducible expression thyroid cancer cell lines were established. Cell sp |
| 요약 | To study the function of RCAN1-4 in endogenous tumor models, thyroid specific RCAN1-4 inducible expression mice and thyroid specific RCAN1-4 knockout mice were also created. The mice were crossed with the DRP-TpoKO and Tg-BRAF thyroid cancer mod |
| 요약 | In summary, we have demonstrated that RCAN1-4 in the cancer cells is a tumor growth and metastasis suppressor, but not a tumor suppressor. We have also identified NFE2L3 as a potential regulator of tumor growth and metastasis in thyroid cancer t |
| 일반주제명 | Cellular biology. Biochemistry. Oncology. |
| 언어 | 영어 |
| 바로가기 | 
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