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Insights Into FHIT Loss-Induced Tumorigenesis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Insights Into FHIT Loss-Induced Tumorigenesis. |
| 개인저자 | Waters, Catherine Elizabeth. |
| 단체저자명 | The Ohio State University. Biomedical Sciences. |
| 발행사항 | [S.l.]: The Ohio State University., 2015. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2015. |
| 형태사항 | 128 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438310131 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2015. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Kay Huebner. |
| 요약 | Cancer cells display an elevated rate of genetic mutation at the single nucleotide and chromosome levels, termed genome instability. Genome instability is a facilitating hallmark of cancer in that it raises the probability of generating cancer-p |
| 요약 | Deletion within fragile site FRA3B, which overlaps exons of the FHIT gene, is a frequent and early genetic alteration in precancerous cells, resulting in reduced or lost Fhit protein expression. Loss of Fhit expression occurs in >50% of human c |
| 요약 | The cellular processes that can exploit Fhit loss-induced DNA damage and allow increased accumulation of genome alterations and point mutations in Fhit deficient cells and tissues have only recently been examined. APOBEC3B cytidine deaminase act |
| 요약 | Using data from The Cancer Genome Atlas, we show that FHIT-low/ APOBEC3B-high expressing lung adenocarcinomas display significantly increased numbers of APOBEC signature mutations. Tumor samples in this cohort with normal FHIT expression do not |
| 요약 | Collectively, these findings support a model where deregulation of the Fhit-TK1 pathway initiates genomic instability in early lesions, providing increased availability of unstable ssDNA regions that can be mutated by enzymes, such as APOBEC3B, |
| 일반주제명 | Biomedical engineering. |
| 언어 | 영어 |
| 바로가기 | 
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