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Toll-like Receptor 4 Regulates Intraspinal and Peripheral Responses after Spinal Cord Injury
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Toll-like Receptor 4 Regulates Intraspinal and Peripheral Responses after Spinal Cord Injury. |
| 개인저자 | Church, Jamie Stoddard. |
| 단체저자명 | The Ohio State University. Neuroscience. |
| 발행사항 | [S.l.]: The Ohio State University., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 256 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438310261 |
| 학위논문주기 | Thesis (Ph.D.)--The Ohio State University, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Dana McTigue. |
| 요약 | Traumatic spinal cord injury (SCI) disrupts not only tissue within the central nervous system (CNS), but homeostatic processes in the periphery as well. Macrophages are immune cells that accumulate in the spinal cord lesion site and in periphera |
| 요약 | In the damaged spinal cord DAMPs initiate secondary injury processes including apoptosis and inflammation. Acutely, cells of the oligodendrocyte (OL) lineage (OLs and their progenitor cells, OPCs) are lost, but this extensive glial cell loss is |
| 요약 | Anemia and pressure ulcers are two common iron-related comorbidities with SCI. Because TLR4 is an innate immune receptor and its signaling in macrophages regulates systemic iron during pathogen invasion we investigated whether TLR4 signaling inf |
| 요약 | In conclusion, my graduate work shows that intraspinal TLR4 signaling alters macrophage iron regulation and myelin debris phagocytosis, and influences each stage of OL lineage cell progression in the healthy adult CNS and/or after SCI and lysole |
| 일반주제명 | Neurosciences. Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
