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Copolymer-based Membrane Stabilizers for Duchenne Muscular Dystrophy
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Copolymer-based Membrane Stabilizers for Duchenne Muscular Dystrophy. |
| 개인저자 | Houang, Evelyne Morgane. |
| 단체저자명 | University of Minnesota. Integrative Biology and Physiology. |
| 발행사항 | [S.l.]: University of Minnesota., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 172 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438170117 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Joseph M. Metzger. |
| 요약 | The overarching objective of this work centers on a structure-function approach to investigate the mechanism of action of synthetic copolymer-based membrane stabilization in the context of Duchenne Muscular Dystrophy (DMD). The guiding theme is |
| 요약 | DMD is an X-linked recessive disease of marked striated muscle deterioration affecting 1 in 3500-5000 boys. DMD results from the lack of the cytoskeletal protein dystrophin, which is essential for maintaining the structural integrity of the musc |
| 요약 | The efficacy of P188 in protecting the dystrophic myocardium has been well established, but its effect on the dystrophic skeletal muscle has remained unclear. This work for the first time demonstrates that P188 stabilizes the dystrophic skeletal |
| 요약 | Very little is known on how P188 interacts with and stabilizes biological membranes. To fundamentally probe the mechanism of action of synthetic copolymers as membrane stabilizers, a structure-function approach was undertaken. The aim was to gai |
| 요약 | Finally, leveraging the power of supercomputational approaches, Molecular Dynamics simulations were developed to further evaluate and understand copolymer-membrane interactions at atom level resolution. Using increases in surface tension applied |
| 일반주제명 | Physiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
