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Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation. |
| 개인저자 | Gruba, Sarah Melissa. |
| 단체저자명 | University of Minnesota. Chemistry. |
| 발행사항 | [S.l.]: University of Minnesota., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 170 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438170162 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Christy L. Haynes. |
| 요약 | This work examines how environmental factors such as lipid membrane concentration, opioid agonist exposure, and inflammatory diseases impact cell communication. It explores the use of different cell models, specifically platelets and mast cells, |
| 요약 | Platelets are cell-like bodies that travel through the bloodstream and are known for their role in hemostasis and diseases like stroke and myocardial infarction. They have also been implicated in inflammatory diseases such as asthma. In addition |
| 요약 | In contrast, mast cells are found throughout the body in connective tissue and are one of the immune system's first lines of defense. They are primarily known for their role in allergies and asthma. Upon detection of antigens that they are sensi |
| 요약 | Chapter One reviews single cell analysis techniques with a particular emphasis on the techniques used in this thesis, including electrochemistry and mass spectrometry. |
| 요약 | Chapter Two through four are focused on understanding how variations in membrane lipids and structure affect platelet function and exocytosis in general. Chapter Two focuses on understanding the variations that the fusion pore undergoes when gra |
| 요약 | Chapter Five and Six progresses from lipid function into developing a better understanding of how platelets respond to their environment, particularly in the context of inflammatory diseases. Chapter Five's focus is on platelet response to opioi |
| 요약 | Chapter Seven and Eight focus on mouse peritoneal mast cell (MPMC) function in the context of inflammatory diseases including allergic asthma and neurogenic inflammation, respectively. Chapter Seven aims to state the importance of understanding |
| 일반주제명 | Chemistry. Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
