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Development and Validation of a Multinuclear Magnetic Resonance Spectroscopy Toolkit for Bioartificial Pancreas Assessment
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Development and Validation of a Multinuclear Magnetic Resonance Spectroscopy Toolkit for Bioartificial Pancreas Assessment. |
| 개인저자 | Einstein, Samuel Aaron. |
| 단체저자명 | University of Minnesota. Biophysical Sciences and Medical Physics. |
| 발행사항 | [S.l.]: University of Minnesota., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 214 p. |
| 기본자료 저록 | Dissertation Abstracts International 80-01B(E). Dissertation Abstract International |
| ISBN | 9780438350632 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Advisers: Michael Garwood |
| 요약 | Type 1 diabetes is a devastating disease with increasing incidence and prevalence. Insulin therapy, while life-saving, does not prevent severe complications that substantially increase both morbidity and mortality. Whole pancreas and pancreatic |
| 요약 | To enable and expedite TEG development, novel techniques to assess oxygen status (pO2) and viability were developed, validated, and applied. Hypoxia is currently the most significant obstruction preventing widespread utilization of TEGs, renderi |
| 요약 | This technique was applied to the murine model and demonstrated that TEGs implanted subcutaneously experience hypoxia unconducive to supporting islet viability and function. Therefore, a method for the delivery of supplemental oxygen (DSO) to in |
| 요약 | While providing crucial information, measuring pO2 does not necessarily correlate to islet viability, necessitating the development of additional techniques. Islet viability was first assessed by measuring pO 2 with 19F-MRS and calculating the o |
| 요약 | Finally, to facilitate in vivo viability assessment and increase measurement accuracy, oxygen-17 MRS was developed to directly measure and noninvasively quantify the OCR of TEGs. |
| 일반주제명 | Medical imaging. Surgery. Physics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
