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Mechanisms of TRAF3 Mediated Regulation of B Cell Survival
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Mechanisms of TRAF3 Mediated Regulation of B Cell Survival. |
| 개인저자 | Mambetsariev, Nurbek. |
| 단체저자명 | The University of Iowa. Immunology. |
| 발행사항 | [S.l.]: The University of Iowa., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 145 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438151161 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Iowa, 2018. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Gail A. Bishop. |
| 요약 | The adaptor protein TNF receptor-associated factor 3 (TRAF3) regulates signaling through B lymphocyte receptors, including CD40, BAFF receptor and Toll-like receptors, and also plays a critical role inhibiting B cell homoeostatic survival. Consi |
| 요약 | We show here that TRAF3 is a resident nuclear protein that associated with the transcriptional regulator cyclic AMP response element binding protein (CREB) in both mouse and human B cells. The TRAF-C domain of TRAF3 was necessary and sufficient |
| 요약 | We also show that TRAF3 deficiency led to induction of two proteins important for glucose metabolism, Glut1 and Hexokinase 2 (HXK2). This was associated with increased glucose uptake. In the absence of TRAF3, anaerobic glycolysis and oxidative p |
| 요약 | Finally, loss of TRAF3 resulted in the induction of the pro-survival kinase proviral insertion in murine lymphoma 2 (Pim2) in B cells independently of non --canonical NF-kappaB activation. TRAF3-deficient B cells and multiple myeloma cells displ |
| 요약 | Collectively, these findings provide insight into how TRAF3 regulates B cell survival. Our improved understanding of how loss of TRAF3 promotes development of B cell malignancies allows for the development of novel therapeutic strategies that ta |
| 일반주제명 | Immunology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
