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Biomedical Applications and Strategies Using Boronic Acids
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Biomedical Applications and Strategies Using Boronic Acids. |
| 개인저자 | Smith, Thomas P. |
| 단체저자명 | The University of Wisconsin - Madison. Chemistry. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2016. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2016. |
| 형태사항 | 358 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-11B(E). Dissertation Abstract International |
| ISBN | 9780438159518 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2016. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Ronald T. Raines. |
| 요약 | Boronic acids have been shown to interact with biological molecules including carbohydrates and reactive oxygen species (ROS). This variety of biological targets is due to the unique reactivity of boron that, within a physiological pH range, can |
| 요약 | The development of therapeutic proteins is generating considerable interest. This interest is due to the high selectivity of proteins for a target and the high enzymatic activity a protein-based therapeutic can possess. There are, however, a num |
| 요약 | In chapter 2, I describe the development of a discreet, small-molecule boronic acid-based delivery strategy for the delivery of native protein into the cytosol of a cell. This was accomplished by appending a specialized boronic acid directly to |
| 요약 | Another challenge with biologic therapeutics is overcoming the potential pleiotropic nature of the particular protein or enzyme. This challenge is explicit in the use of angiogenin (ANG) as a potential treatment of amyotrophic lateral sclerosis |
| 요약 | In chapter 3, I highlight a specific masking strategy that silences the catalytic activity of ANG under normal physiological conditions. When exposed to reactive oxygen species (ROS) leading to oxidative stress, this mask is removed, and catalyt |
| 요약 | In ALS, the up-regulation of ROS in the central nervous system (CNS) is primarily responsible for the motor neuron degeneration characteristic of the disease. The presence of a boronic acid-masking agent engenders ANG with pro-drug characteristi |
| 요약 | Boronic acids have also been utilized as important functional groups in medicinal chemistry. For example, VelcadeRTM (bortezomib), is a first-in-class boronic acid-containing protease inhibitor and the first boronic acid drug to be approved by t |
| 요약 | In chapter 4, I discuss the development and characterization of a targeted library of small-molecule boronic acids that bind to the thyroxin (T 4) binding pockets and strongly inhibit fibril formation in both wild-type and a common disease varia |
| 일반주제명 | Biochemistry. Chemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
