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The Genetics of Aromatase Inhibitor-related Phenotypes in Postmenopausal Women with ER+ Breast Cancer
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Genetics of Aromatase Inhibitor-related Phenotypes in Postmenopausal Women with ER+ Breast Cancer. |
| 개인저자 | Dudenkov, Tanda Tosia Murray. |
| 단체저자명 | College of Medicine - Mayo Clinic. Molecular Pharmacology and Experimental Therapeutics. |
| 발행사항 | [S.l.]: College of Medicine - Mayo Clinic., 2017. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2017. |
| 형태사항 | 257 p. |
| 기본자료 저록 | Dissertation Abstracts International 79-12B(E). Dissertation Abstract International |
| ISBN | 9780438272019 |
| 학위논문주기 | Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2017. |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Richard M. Weinshilboum. |
| 요약 | Breast cancer is the most common invasive cancer diagnosed in women worldwide, and is responsible for more than 230,000 annual deaths in the United States. Early stage breast tumors are sub-classified based on their hormone receptor status, with |
| 요약 | Anastrozole is a non-steroidal, reversible, competitive inhibitor of aromatase, and is the most commonly prescribed AI in the United States. However, it is universally administered in only one dose, 10 mg/day, without regard for pre-treatment es |
| 요약 | As an initial step towards achieving these goals, the first part of this dissertation sought to fill the vacuum of knowledge concerning genetic contributors to variation in plasma concentrations of hormones in the estrone biosynthesis pathway in |
| 요약 | The second part of this dissertation focused on the discovery of genetic determinants of plasma anastrozole concentrations and the application of those variants in predicting tangible clinical outcomes in postmenopausal women with ER+ breast can |
| 일반주제명 | Genetics. Pharmacology. Oncology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
