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The Relationship between Cerebral Blood Flow and Neuropsychological Outcomes in Veterans with History of Mild Traumatic Brain Injury
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Relationship between Cerebral Blood Flow and Neuropsychological Outcomes in Veterans with History of Mild Traumatic Brain Injury. |
| 개인저자 | Clark, Alexandra L. |
| 단체저자명 | University of California, San Diego. Clinical Psychology (Joint Doctoral with SDSU). |
| 발행사항 | [S.l.]: University of California, San Diego., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 91 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04A. Dissertation Abstract International |
| ISBN | 9781085677608 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, San Diego, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: A.
Advisor: Delano-Wood, Lisa M. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Rationale. Though the short and long-term consequences of neurotrauma are only beginning to be appreciated, those with history of mild traumatic brain injury (TBI) show increased rates of psychiatric disorders, decreased quality of life, and cognitive deficits relative to those with no history of mTBI. Potentially important, though vastly understudied, is the role of the cerebrovascular system in cognitive outcomes after mild TBI. Primary injury to the cerebrovasculature (i.e., stretching and shearing of vessels) coupled with secondary pathophysiological processes (e.g., ischemia, neuroinflammation, vascular remodeling) may alter cerebral blood flow (CBF) post-injury. Such CBF changes may negatively affect the brain's process of post-traumatic repair and contribute to poor long-term outcomes. However, the contribution of CBF to cognitive dysfunction post-injury remains incompletely characterized, and no known human studies have investigated how important genetic and environmental risk factors (i.e., cumulative number of sub-concussive blasts, history of multiple TBIs, time since injury, apolipoprotein E [APOE]-琯4 genotype) may moderate CBF and cognitive associations.Design. The current study utilized multi-phase pseudo-continuous arterial spin labeling neuroimaging methods to (1) evaluate whether resting CBF differences occur in those with history of TBI, (2) investigate the relationship between resting CBF and neuropsychological function, and (3) in exploratory analyses, examine possible moderators of resting CBF and cognition in those with history of mTBI. We recruited and enlisted 54 OEF/OIF/OND service members between the ages of 18 and 50 for this study. Study groups include those with history of mild or moderate TBI (n = 31) and military controls with no history of TBI (n = 23). Analyses of covariance controlling for age and symptoms of posttraumatic stress and depression were used to explore group differences in resting CBF of the whole brain as well as bilateral frontal and temporal regions of interest. Multiple regression analyses were performed within the TBI group to assess whether resting CBF in bilateral frontal and temporal ROIs was predictive of performance on measures of executive functioning and memory |
| 일반주제명 | Clinical psychology. Cognitive psychology. Neurosciences. Military studies. |
| 언어 | 영어 |
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