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A Synthetic Biochemistry Platform for the Enzymatic Synthesis of Cannabinoids and Other Prenylated Natural Products
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | A Synthetic Biochemistry Platform for the Enzymatic Synthesis of Cannabinoids and Other Prenylated Natural Products. |
| 개인저자 | Valliere, Meaghan Ann. |
| 단체저자명 | University of California, Los Angeles. Molecular Biology 0573. |
| 발행사항 | [S.l.]: University of California, Los Angeles., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 121 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-02B. Dissertation Abstract International |
| ISBN | 9781085687478 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Los Angeles, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Advisor: Bowie, James. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Natural products possess amazing medicinal properties, but in order to capitalize on them we need reproducible and efficient methods to produce them. While this usually means a chemical synthesis approach, natural products can have intricate structures with multiple chiral centers, making synthesis too difficult or expensive. For many complex molecules, bio-based approaches can be advantageous (reviewed in Chapter 1). Cannabinoids are an exciting class of complex natural products that interact with the human endocannabinoid receptors, and have considerable therapeutic potential. Cannabinoids are usually extracted from the cannabis plant and some synthetic routes have been developed. However, due to the high demand for pharmaceutical grade cannabinoids, there are growing efforts to develop a more sustainable and more cost-effective bio-based approach, by metabolic engineering of living organisms. Herein, I test an alternative approach to bio-based cannabinoid production using cell-free enzymatic synthesis, an approach we call synthetic biochemistry. |
| 일반주제명 | Biochemistry. Physiology. Public health. Alternative medicine. |
| 언어 | 영어 |
| 바로가기 | 
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