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Isw2 and Ino80 Complexes Regulate the Ribosomal DNA Locus and DNA Break Repair Choice
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Isw2 and Ino80 Complexes Regulate the Ribosomal DNA Locus and DNA Break Repair Choice. |
| 개인저자 | Cutler, Samuel R. |
| 단체저자명 | University of Washington. Molecular and Cellular Biology. |
| 발행사항 | [S.l.]: University of Washington., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 115 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
| ISBN | 9781085714853 |
| 학위논문주기 | Thesis (Ph.D.)--University of Washington, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Tsukiyama, Toshio. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | To achieve the high degree of compaction required to fit the eukaryotic genome into a nucleus, DNA has evolved to be organized in a structure referred to as chromatin. Chromatin involves the tight interaction of DNA with histone octamers known as nucleosomes. Because this association between DNA and nucleosomes inhibits DNA-dependent processes, chromatin structure is carefully regulated to facilitate transcription of RNAs from the DNA template, repair of DNA damage, and replication of the genome. ATP-dependent chromatin remodeling factors use the energy of ATP hydrolysis to modify specific features of chromatin structure. In this dissertation, I focus on elucidating biological functions of the Saccharomyces cerevisiae remodeling factors Isw2 and Ino80. I show that these complexes are targeted to the yeast ribosomal DNA locus, where they modify local chromatin structure and regulate replication initiation from this genomic locus and changes of the size of the highly repetitive rDNA array. In addition, I show evidence supporting possible roles for Isw2 and Ino80 in regulating the balance between two mechanisms of repair of DNA double strand breaks. In sum, my work establishes novel functions for these chromatin remodeling factors at a uniquely repetitive and important part of the eukaryotic genome and in a process that is crucial for genome stability. |
| 일반주제명 | Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
