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Elucidation of the Biogenesis of the Paraherquamides, Malbrancheamides, Citrinalins, and Brevianamides
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Elucidation of the Biogenesis of the Paraherquamides, Malbrancheamides, Citrinalins, and Brevianamides. |
| 개인저자 | Klas, Kimberly R. |
| 단체저자명 | Colorado State University. Chemistry. |
| 발행사항 | [S.l.]: Colorado State University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 336 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088301494 |
| 학위논문주기 | Thesis (Ph.D.)--Colorado State University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Williams, Robert M. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Various fungi of the genera Aspergillus, Penicillium and Malbranchea produce prenylated indole alkaloids that possess a bicyclo[2.2.2]diazaoctane ring system and a variety of biological activities such as insecticidal, cytotoxic, anthelmintic, and antibacterial properties. After the discovery of distinct enantiomers of the natural alkaloids Stephacidin A, Notoamide B and their corresponding diastereomers, from Aspergillus protuberus MF297-2, Aspergillus amoenus NRRL 35660 and Aspergillus taichungensis, the structurally diverse metabolites became of particular biosynthetic interest. The bicyclo[2.2.2]diazaoctane core of the divergent natural metabolites may be enzymatically derived via a putative intramolecular hetero-Diels-Alder cycloaddition. We completed the total synthesis of ZwtP and MeZwtP, unveiling the role of a newly discovered Diels-Alderase. We are also undergoing further synthetic efforts to access other novel natural products, as well as further understand additional unprecedented transformations in nature. |
| 일반주제명 | Chemistry. |
| 언어 | 영어 |
| 바로가기 | 
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