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Utilizing Chemoproteomic Platforms to Elucidate Toxicological Mechanisms
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Utilizing Chemoproteomic Platforms to Elucidate Toxicological Mechanisms. |
| 개인저자 | Ford, Breanna. |
| 단체저자명 | University of California, Berkeley. Endocrinology. |
| 발행사항 | [S.l.]: University of California, Berkeley., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 141 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781085781961 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Berkeley, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Nomura, Daniel. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | A large number of pharmaceuticals, endogenous metabolites, and environmental chemicals act through covalent mechanisms with protein targets. Yet, their specific interactions with the proteome still remain poorly defined for most of these reactive chemicals. Deciphering direct protein targets of reactive small-molecules is critical in understanding their biological action, off-target effects, and potential toxicological liabilities, as well as for the development of safer and more selective chemical agents. Chemoproteomic technologies have arisen as a powerful strategy that enables the assessment of proteome-wide interactions of these irreversible agents directly in complex biological systems. In Chapter one, we review several chemoproteomic strategies that have facilitated our understanding of specific protein interactions of irreversibly-acting pharmaceuticals, endogenous metabolites, and environmental electrophiles to reveal novel pharmacological, biological, and toxicological mechanisms.The usefulness of chemoproteomic platforms in assessing the toxicity of environmental chemicals is further demonstrated in Chapter two |
| 일반주제명 | Toxicology. Endocrinology. Biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
