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Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry. |
| 개인저자 | Huang, Xiaoxiao. |
| 단체저자명 | Northwestern University. Interdepartmental Biological Sciences (IBiS) Graduate Program. |
| 발행사항 | [S.l.]: Northwestern University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 155 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-05B. Dissertation Abstract International |
| ISBN | 9781687943507 |
| 학위논문주기 | Thesis (Ph.D.)--Northwestern University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Advisor: Kelleher, Neil L. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic regulators through chromosomal translocations, mutations, and deletions is highly associated with tumorigenesis. NSD2 (MMSET/WHSC1) is a histone methyltransferase that catalyzes di-methylation of histone H3 lysine 36 (H3K36me2), a mark associated with gene activation. The overexpression of NSD2 in t(4 |
| 일반주제명 | Molecular biology. Analytical chemistry. Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
