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Engineering the Interface: Hyaluronic Acid Hydrogels that Mediate MSC Chondrogenesis for Cartilage Tissue Engineering

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서명/저자사항Engineering the Interface: Hyaluronic Acid Hydrogels that Mediate MSC Chondrogenesis for Cartilage Tissue Engineering.
개인저자Kwon, Mi Y.
단체저자명University of Pennsylvania. Bioengineering.
발행사항[S.l.]: University of Pennsylvania., 2019.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2019.
형태사항195 p.
기본자료 저록Dissertations Abstracts International 81-03B.
Dissertation Abstract International
ISBN9781088370216
학위논문주기Thesis (Ph.D.)--University of Pennsylvania, 2019.
일반주기 Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Burdick, Jason A.
이용제한사항This item must not be sold to any third party vendors.This item must not be added to any third party search indexes.
요약Articular cartilage injury and progressive degeneration, combined with the clinical needs that result from an aging population and increasing rates of diagnosed osteoarthritis, have created a burgeoning demand for therapies aimed at cartilage repair. One approach that has gained traction is the delivery of clinically relevant cell types such as mesenchymal stromal cells to the injury site using hydrogels, which are water-swollen polymer networks that can be engineered to suit a wide variety of applications. Previous insights have led us to identify the roles of parameters such as cellular density, matrix degradation, mechanical loading, and even cell-cell communication in engineered cartilage formation and maturation. These hydrogels often employ biomaterials such as hyaluronic acid that are native to the body and intended to influence cell behavior. However, hydrogel-based therapies to date have predominantly focused on permitting or facilitating the eventual maturation of cartilage tissue by enabling matrix remodeling and distribution
일반주제명Bioengineering.
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