자료유형 | 학위논문 |
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서명/저자사항 | Engineering the Interface: Hyaluronic Acid Hydrogels that Mediate MSC Chondrogenesis for Cartilage Tissue Engineering. |
개인저자 | Kwon, Mi Y. |
단체저자명 | University of Pennsylvania. Bioengineering. |
발행사항 | [S.l.]: University of Pennsylvania., 2019. |
발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
형태사항 | 195 p. |
기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
ISBN | 9781088370216 |
학위논문주기 | Thesis (Ph.D.)--University of Pennsylvania, 2019. |
일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Burdick, Jason A. |
이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
요약 | Articular cartilage injury and progressive degeneration, combined with the clinical needs that result from an aging population and increasing rates of diagnosed osteoarthritis, have created a burgeoning demand for therapies aimed at cartilage repair. One approach that has gained traction is the delivery of clinically relevant cell types such as mesenchymal stromal cells to the injury site using hydrogels, which are water-swollen polymer networks that can be engineered to suit a wide variety of applications. Previous insights have led us to identify the roles of parameters such as cellular density, matrix degradation, mechanical loading, and even cell-cell communication in engineered cartilage formation and maturation. These hydrogels often employ biomaterials such as hyaluronic acid that are native to the body and intended to influence cell behavior. However, hydrogel-based therapies to date have predominantly focused on permitting or facilitating the eventual maturation of cartilage tissue by enabling matrix remodeling and distribution |
일반주제명 | Bioengineering. |
언어 | 영어 |
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: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |