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Secretory IgA Enhances Gut B Cells Priming and Systemic IgG Responses Towards Commensals
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Secretory IgA Enhances Gut B Cells Priming and Systemic IgG Responses Towards Commensals. |
| 개인저자 | Zhou, You. |
| 단체저자명 | Washington University in St. Louis. Biology & Biomedical Sciences (Immunology). |
| 발행사항 | [S.l.]: Washington University in St. Louis., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 93 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-05B. Dissertation Abstract International |
| ISBN | 9781088384282 |
| 학위논문주기 | Thesis (Ph.D.)--Washington University in St. Louis, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Advisor: Hsieh, Chyi S. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | IgA is the primary antibody response at mucosal surfaces and is reported to inhibit adaptive immune responses against gut bacteria. Here, we utilize an in vitro system to expand and screen IgA memory B cells for their ability to recognize gut bacteria in the context of secretory IgA (sIgA) deficiency in polymeric Ig receptor (Pigr-/-) mice. Contrary to the prevailing hypothesis that IgA provides an immune exclusionary function, we found that mice lacking sIgA showed decreased anti-bacterial IgA specificities as assessed using flow cytometry. IgA B cell responses against certain taxa such as those of order Bacteriodales showed greater dependence on sIgA. Notably, sIgA also facilitated the generation of anti-bacterial IgG B cells, which provided increased resistance to intraperitoneal infection by commensal bacteria. Together, these data suggest that sIgA can facilitate the immune priming of gut commensals to increase anti-bacterial IgA and IgG and enhance immunity. |
| 일반주제명 | Immunology. Biology. Microbiology. Physiology. Health sciences. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
