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The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location. |
| 개인저자 | Walsh, Daniel. |
| 단체저자명 | University of Minnesota. Microbiology, Immunology and Cancer Biology. |
| 발행사항 | [S.l.]: University of Minnesota., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 78 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088375594 |
| 학위논문주기 | Thesis (Ph.D.)--University of Minnesota, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Jameson, Stephen C. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Recent studies have characterized populations of memory CD8+ T cells that do not recirculate through the blood but are instead retained in non-lymphoid tissues. Such resident memory CD8+ T cells (TRM) are critical for pathogen control at barrier sites. Identifying TRM and defining the basis for their tissue residency is therefore of considerable importance for understanding protective immunity and improved vaccine design. Expression of the molecule CD69 is widely used as a definitive marker for TRM, yet it is unclear whether CD69 is universally required for producing or retaining TRM. Using multiple mouse models of acute immunization, we found that the functional requirement for CD69 was highly variable depending on the tissue examined, playing no detectable role in generation of TRM at some sites (such as the small intestine), while CD69 was critical for establishing resident cells in the kidney. Likewise, forced expression of CD69 (but not expression of a CD69 mutant unable to bind the egress factor S1PR1) promoted CD8+ TRM generation in the kidney but not in other tissues. Our findings indicate that the functional relevance of CD69 in generation and maintenance of CD8+ TRM varies considerably, chiefly dependent on the specific non-lymphoid tissue studied. Together with previous reports that suggest uncoupling of CD69 expression and tissue-residency, these findings prompt caution in reliance on CD69 expression as a consistent marker of CD8+ TRM. |
| 일반주제명 | Immunology. |
| 언어 | 영어 |
| 바로가기 | 
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