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Simulating Drug Responses in Laboratory Test Time Series with Deep Generative Modeling
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Simulating Drug Responses in Laboratory Test Time Series with Deep Generative Modeling. |
| 개인저자 | Yahi, Alexandre. |
| 단체저자명 | Columbia University. Biomedical Informatics. |
| 발행사항 | [S.l.]: Columbia University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 304 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
| ISBN | 9781085742139 |
| 학위논문주기 | Thesis (Ph.D.)--Columbia University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Tatonetti, Nicholas . |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Drug effects can be unpredictable and vary widely among patients with environmental, genetic, and clinical factors. Randomized control trials (RCTs) are not sufficient to identify adverse drug reactions (ADRs), and the electronic health record (EHR) along with medical claims have become an important resource for pharmacovigilance. Among all the data collected in hospitals, laboratory tests represent the most documented and reliable data type in the EHR. Laboratory tests are at the core of the clinical decision process and are used for diagnosis, monitoring, screening, and research by physicians. They can be linked to drug effects either directly, with therapeutic drug monitoring (TDM), or indirectly using drug laboratory effects (DLEs) that affect surrogate tests. Unfortunately, very few automated methods use laboratory tests to inform clinical decision making and predict drug effects, partly due to the complexity of these time series that are irregularly sampled, highly dependent on other clinical covariates, and non-stationary. Deep learning, the branch of machine learning that relies on high-capacity artificial neural networks, has known a renewed popularity this past decade and has transformed fields such as computer vision and natural language processing. Deep learning holds the promise of better performances compared to established machine learning models, although with the necessity for larger training datasets due to their higher degrees of freedom. These models are more flexible with multi-modal inputs and can make sense of large amounts of features without extensive engineering. Both qualities make deep learning models ideal candidate for complex, multi-modal, noisy healthcare datasets.With the development of novel deep learning methods such as generative adversarial networks (GANs), there is an unprecedented opportunity to learn how to augment existing clinical dataset with realistic synthetic data and increase predictive performances. Moreover, GANs have the potential to simulate effects of individual covariates such as drug exposures by leveraging the properties of implicit generative models. In this dissertation, I present a body of work that aims at paving the way for next generation laboratory test-based clinical decision support systems powered by deep learning. To this end, I organized my experiments around three building blocks: (1) the evaluation of various deep learning architectures with laboratory test time series and their covariates with a forecasting task |
| 일반주제명 | Bioinformatics. Artificial intelligence. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
