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Gene Set-based Signal-Detection Analyses with Goodness-of-Fit Statistics and Their Application in Complex Diseases
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Gene Set-based Signal-Detection Analyses with Goodness-of-Fit Statistics and Their Application in Complex Diseases. |
| 개인저자 | Zhang, Mengqi. |
| 단체저자명 | Duke University. Computational Biology and Bioinformatics. |
| 발행사항 | [S.l.]: Duke University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 117 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088333884 |
| 학위논문주기 | Thesis (Ph.D.)--Duke University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Allen, Andrew S. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Rare diseases are difficult to diagnose and uncertain to treat. The identification of specific genes associated with particular rare diseases and phenotypes can provide insight into the mechanism of certain rare disease subtypes and suggest therapeutic targets to improve patient outcomes. However, single gene-based methods for detecting rare disease-associated variants are often underpowered and can be hard to interpret. Therefore, this dissertation explores alternative approaches based on gene set-based methods. These analyses can be solved with a goodness-of-fit test that assesses whether the distribution of observed statistics of a given set of genes/variants significantly differs from the expected distribution. This dissertation explores a flexible gene set-based signal-detection framework based on the goodness-of-fit tests. A user-friendly and efficient R program was developed for this research. In addition, this dissertation proposes a new gene-set analyses method that can leverage prior information to inform the detection of whether any of the genes within a biologically informed gene-set is associated with disease phenotypes on a special goodness-of-fit a test called higher criticism. Further, this dissertation investigates the asymptotic distribution of our higher criticism statistic based on the theoretically weighted p-values. Collectively, these methods are innovative because they based on gene set and incorporate the prior information, which enhances the power of associations between rare variants and complex diseases. These results improve the ability to identify and optimally treat genetic disease subtypes. |
| 일반주제명 | Biostatistics. Genetics. Physiology. Statistics. Health sciences. Epidemiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
