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Understanding the Role of Polarity Regulators in Irradiated Salivary Glands Following Injury and During Regeneration
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Understanding the Role of Polarity Regulators in Irradiated Salivary Glands Following Injury and During Regeneration. |
| 개인저자 | Wong, Wen Yu. |
| 단체저자명 | The University of Arizona. Cancer Biology. |
| 발행사항 | [S.l.]: The University of Arizona., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 149 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-05B. Dissertation Abstract International |
| ISBN | 9781687905208 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Arizona, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Advisor: Limesand, Kirsten. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Approximately 600,000 patients are diagnosed with head and neck cancer (HNC) worldwide with a 40-50% mortality rate each year. Malfunctioning salivary glands and consequential xerostomia is a common and chronic complication for patients treated with radiotherapy for HNC. While significant improvements have been achieved in the prevention and treatment of radiation-induced hyposalivation, many patients still suffer from xerostomia and other oral complications. This implies that the above-described strategies are not sufficient in restoring salivary function and secretion. Though there are efforts directed toward gene therapy, artificial salivary glands, and stem cell transplantation, these techniques are not fully standardized, nor clinically applicable yet. Considerable research efforts have focused on the role of radiation damage on the stem/progenitor cells (SPCs). Just as important, restoration of the salivary glands requires an understanding of the spatial and temporal interactions of its environment since it provides paracrine and mechanical signals to maintain the SPCs. Polarity, the intrinsic asymmetry of cellular components, plays a role in the reestablishment of the epithelization process that is necessary for directional salivary secretion. While polarity has been shown to be important in salivary development, homeostasis, and maintenance, the effects of radiation on polarity in the total parotid tissue remain largely unknown. The question of what polarity regulators are damaged, how they are damaged, and if they respond during tissue regeneration is still elusive. We propose that by understanding the role of polarity regulators following injury and during tissue regeneration, we would be able to elucidate some mechanistic insights that govern radiation-induced salivary dysfunction. |
| 일반주제명 | Molecular biology. Physiology. Surgery. Public health. Oncology. Health sciences. Health care management. Radiation. |
| 언어 | 영어 |
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: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
