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Elucidating the Diversity, Distribution and Function of the Gut Bacterial Symbiont Ruminococcus
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Elucidating the Diversity, Distribution and Function of the Gut Bacterial Symbiont Ruminococcus. |
| 개인저자 | La Reau, Alex J. |
| 단체저자명 | The University of Wisconsin - Madison. Microbiology ALS. |
| 발행사항 | [S.l.]: The University of Wisconsin - Madison., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 274 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781687907837 |
| 학위논문주기 | Thesis (Ph.D.)--The University of Wisconsin - Madison, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Suen, Garret. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | All animals live in close symbiosis with communities of microorganisms both in and on their bodies. Among the microbial communities of some animals species, including humans, is a bacterial genus named Ruminococcus. Species members of this genus have been actively studied since their discovery, and their functional roles within their hosts with respect to health and disease are of great interest to researchers of the microbiome of humans, bovine ruminants, and other mammalian gut ecosystems. Despite the work done on various species members of the genus, unanswered questions about the diversity and environmental distribution of these species remain. Moreover, it is unclear how these organisms are transmitted from parent to offspring as they are not known to form bacterial endospores. Furthermore, the cellulolytic members of the genus are the most well-studied, yet key questions remain regarding the cellulolytic strategy of R. albus 7, one of the main cellulose degraders in the bovine rumen environment. In Chapter 2 of this thesis work, demonstrate the unexplored diversity and extent of environmental distribution among disparate hosts for this genus. In Chapter 3, I expand upon this work by exploring some of the functional genomic potential of the ruminococci as host-associated organisms, and I possible mechanisms of generational transmission. In Chapter 4, I provide new insights into the cellulolytic strategy of R. albus 7, including how it may regulate its cellulolytic machinery and how it may compete for fiber degradation in the rumen environment. Finally, in Chapter 5, I leverage data from Chapter 4 to functionally characterize key fiber-degrading enzymes of interest. From this, I re-contextualize the results of Chapter 4 in light of these findings and provide potential future directions and applications of this work. |
| 일반주제명 | Microbiology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
