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Long-distance Non-self Recognition and Control of Intercellular Communication in Neurospora crassa
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Long-distance Non-self Recognition and Control of Intercellular Communication in Neurospora crassa. |
| 개인저자 | Rosenfield, Gabriel R. |
| 단체저자명 | University of California, Berkeley. Microbiology. |
| 발행사항 | [S.l.]: University of California, Berkeley., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 156 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-06B. Dissertation Abstract International |
| ISBN | 9781392717837 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Berkeley, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-06, Section: B.
Advisor: Glass, Nancy L. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | All multicellular organisms face a challenge: resources must be distributed throughout their bodies to ensure continued growth and coordinate cellular activities, but once resources are socialized, how can cells be coerced into working for the organism as a whole, rather than individually reproducing at the expense of the body they inhabit? Solutions to this freeloader problem usually rely on aligning the reproductive interests of all cells in a body by ensuring all are genetically identical. However, such solutions pose problems for organisms with indeterminate colonial growth habits, a lifestyle characterized by vegetative expansion, fragmentation, and reintegration of separated fragments. The filamentous fungus Neurospora crassa exemplifies this lifestyle. Its body is a cross-linked syncytial network produced by the fusion of many cells. Individual nuclei flow throughout the colony, making all the products of each nucleus potentially available to freeloaders. To keep the reproductive interests of all nuclei aligned, N. crassa must restrict fusion to genetically cells. The fungus prevents non-self fusion using an array of non-self recognition (NSR) systems.NSR systems are encoded by polymorphic kind recognition loci. Each NSR locus enables cells to behave differently toward other individuals with the same haplotype than they do toward individuals with distinct haplotypes. At least two haplotypes at an NSR locus must exist in a population for the system to function. If many NSR loci are spread throughout an organisms genome, the net output of all NSR systems transitions to kin recognition |
| 일반주제명 | Microbiology. Cellular biology. Molecular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
