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Natural Secretory Immunoglobulins Facilitate Enteric Viral Infection
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Natural Secretory Immunoglobulins Facilitate Enteric Viral Infection. |
| 개인저자 | Turula, Holly. |
| 단체저자명 | University of Michigan. Immunology. |
| 발행사항 | [S.l.]: University of Michigan., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 182 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-05B. Dissertation Abstract International |
| ISBN | 9781687927965 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2018. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Advisor: Moore, Bethany B. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Noroviruses are enteric pathogens causing significant morbidity, mortality and economic losses worldwide. Secretory immunoglobulins (SIg) are a first line of mucosal defense against enteric pathogens. They are secreted into the intestinal lumen via the polymeric immunoglobulin receptor (pIgR), where they bind to antigens. However, whether natural SIg protect against norovirus infection remains unknown. To determine if natural SIg alter murine norovirus (MNV) pathogenesis, I infected pIgR knockout (KO) mice, which lack SIg in mucosal secretions. Acute MNV infection was significantly reduced in pIgR KO mice compared to controls, despite increased MNV target cells in the Peyer's patch. Natural SIg did not alter MNV binding to, or crossing, of the follicle-associated epithelium (FAE) into the lymphoid follicle. Instead, naive pIgR KO mice have enhanced levels of the antiviral inflammatory molecules interferon gamma (IFN-g) and inducible nitric oxide synthase (iNOS) in the ileum compared to controls. Strikingly, depletion of the intestinal microbiota in pIgR KO and control mice resulted in comparable IFN-g and iNOS levels, as well as MNV infectious titers. IFN-g treatment of WT mice and neutralization of IFN-g in pIgR KO mice modulated MNV titers, implicating this antiviral cytokine in the phenotype. Reduced gastrointestinal infection in pIgR KO mice was also observed with another enteric virus, reovirus. Collectively, my findings suggest that natural SIg are not protective during enteric virus infection, but rather that SIg promote enteric viral infection through alterations in microbial immune responses. |
| 일반주제명 | Epidemiology. Immunology. Virology. |
| 언어 | 영어 |
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: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
