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Quantifying Temperature's Effect on the Cardiovascular System
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Quantifying Temperature's Effect on the Cardiovascular System. |
| 개인저자 | Crouch, Anna Colleen . |
| 단체저자명 | University of Michigan. Mechanical Engineering. |
| 발행사항 | [S.l.]: University of Michigan., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 137 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-05B. Dissertation Abstract International |
| ISBN | 9781687935502 |
| 학위논문주기 | Thesis (Ph.D.)--University of Michigan, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Advisor: Greve, Joan M. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Hippocrates in 370 BC made the first recorded mention of the use of heat as a therapeutic. To this day, the effect of temperature on the body is of interest to clinicians, athletes, researchers, and perhaps anyone that has lived through Georgia summers or Michigan winters. The body maintains temperature homeostasis by the process of thermoregulation. The body's ability to thermoregulate is an important coping mechanism to withstand various physiological states, such as fever, and environmental exposures such as the weather. The cardiovascular (CV) system plays a vital role in thermoregulation because of its influence on heat transfer via forced convection and conduction by changes in blood distribution, blood velocity, and proximity of tissues. It remains unclear how the allocation of blood in various compartments (such as the innermost core, fat, muscle, and skin) changes with temperature. Challenges in measuring core vasculature have resulted in a lack of empirical information regarding how it might change with core temperature. Therefore, to fully understand the CV system's role in thermoregulation, this thesis focuses on using murine models to study the effect of temperature on core vasculature. The overall purpose is to provide a novel and physiologically accurate approach to studying thermoregulation by incorporating structural and functional changes in the CV system occurring in the core.Using murine models and MRI, we noninvasively quantified structural and functional vascular response in core arteries and veins to increasing core body temperature. We also studied the effects of sex and age on the CV response to increasing temperature. Using a PID-controlled heater to blow hot air across the animals, core temperature was increased from mild hypothermia (35째C) to mild hyperthermia (38째C). At each temperature, we imaged three to four locations of the body from head-to-toe, and quantified blood flow and velocity, vessel area, and measured circumferential cyclic strain of the core vessels. Our most significant quantitative results include: cross-sectional area of the aorta increased significantly and linearly with temperature for all groups, but at a diminished rate for aged animals (male and female: adult, 0.019 and 0.024 mm2/째C |
| 일반주제명 | Biomedical engineering. Mechanical engineering. |
| 언어 | 영어 |
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