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Hepatoprotective Mechanisms of Eicosapentaenoic Acid in High-Fat Fed Mice and Identification of Biomarkers for Non-alcoholic Fatty Liver Disease in Humans
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Hepatoprotective Mechanisms of Eicosapentaenoic Acid in High-Fat Fed Mice and Identification of Biomarkers for Non-alcoholic Fatty Liver Disease in Humans. |
| 개인저자 | Albracht-Schulte, Kembra. |
| 단체저자명 | Texas Tech University. Nutritional Sciences. |
| 발행사항 | [S.l.]: Texas Tech University., 2018. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2018. |
| 형태사항 | 194 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-03B. Dissertation Abstract International |
| ISBN | 9781088315408 |
| 학위논문주기 | Thesis (Ph.D.)--Texas Tech University, 2018. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
|
| 요약 | Non-alcoholic fatty liver disease (NAFLD) is a rising epidemic, in part due to its association with obesity and obesity-related metabolic abnormalities. However, therelationship between body weight, NAFLD, and insulin resistance is not well characterized in humans, especially in populations that develop metabolic complications at lower body mass index, such as South Asians. Therefore, research that can lead to effective diagnostic as well as prevention/ treatment strategies for NAFLD and related diseases is greatly needed.Several studies in animal and humans used dietary interventions, such as omega-3 (n-3) polyunsaturated fatty acids (PUFAs), to reduce NAFLD as well as inflammationrelated metabolic disorders. While the anti-inflammatory and hypotriglyceridemic properties of n-3 PUFAs are well-known, mechanisms mediating their benefits in liver and in NAFLD are less understood. Previous studies in our lab have shown reduced hepatic triglyceride accumulation, despite similar body weights, between high-fat fed mice and those supplemented with eicosapentaenoic acid (EPA), a metabolite of n-3 PUFA. Hence, our objectives were: 1. Determine metabolic, inflammatory, and molecular changes in serum biomarkers in humans with NAFLD, and determine whether these are independent of body weight |
| 일반주제명 | Nutrition. Endocrinology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
