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Live Cell Interferometry: A Novel Quantitative Phase Imaging Technique for Rapid Characterizations of Tumor Heterogeneity, Drug Resistance, Cell Fates and Biophysical Properties
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Live Cell Interferometry: A Novel Quantitative Phase Imaging Technique for Rapid Characterizations of Tumor Heterogeneity, Drug Resistance, Cell Fates and Biophysical Properties. |
| 개인저자 | Huang, Dian. |
| 단체저자명 | University of California, Los Angeles. Bioengineering 0288. |
| 발행사항 | [S.l.]: University of California, Los Angeles., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 219 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781687979865 |
| 학위논문주기 | Thesis (Ph.D.)--University of California, Los Angeles, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Includes supplementary digital materials. Advisor: Teitell, Michael Alan. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Cell mass is an important biophysical property that provides a crucial link between external physical measurements and internal cellular processes such as cell cycle progression, division, differentiation and cell death. Advancements in quantitative phase imaging (QPI) techniques have enabled many in-depth studies of cell mass in the context of basic and translational research. This thesis describes the development and implementation of live cell interferometry (LCI) as a novel QPI technique that is high speed, high throughput, precise and label-free. It was validated as a powerful tool in dissecting tumor heterogeneity and drug resistance in patient derived melanoma cell lines. LCI analysis of cell fate in response to mitotic inhibitors provided valuable insights in cancer drug development and dose selection. Furthermore, it was utilized to characterize many other biophysical responses in fundamental research such as cardiomyocyte hypertrophy in cardiac wound healing responses. These studies showcased the unique capabilities and advantages of LCI in applications from bench to bedside. |
| 일반주제명 | Bioengineering. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
