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The Intersection of Maternal Inflammatory Stress and the Developmental Origins of Health and Disease
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Intersection of Maternal Inflammatory Stress and the Developmental Origins of Health and Disease. |
| 개인저자 | Barke, Theresa Leigh. |
| 단체저자명 | Vanderbilt University. Microbiology and Immunology. |
| 발행사항 | [S.l.]: Vanderbilt University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 242 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781085777728 |
| 학위논문주기 | Thesis (Ph.D.)--Vanderbilt University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Aronoff, David M. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | The most important factor influencing the prenatal environment is the maternal environment. There is a growing body of evidence suggesting that the maternal and intrauterine milieu, through the action of inflammatory mediators may permanently change the health of the fetus. Gestational diabetes mellitus (GDM) is the most common metabolic disorder during pregnancy and is associated with aberrant systemic inflammation and known to cause considerable morbidity, mortality, and long-term complications for both mother and child. Maternal immune activation (MIA), another prenatal insult, is common and occurs as the result of an infection during pregnancy. Several epidemiological as well as clinical studies have shown associations between infection and MIA during pregnancy and an increased risk for developing neurocognitive disorders such as autism and schizophrenia in offspring. The aberrant inflammation caused by GDM and maternal obesity is also gaining evidence as a possible cause for the same neurocognitive disorders. For progress to be made in the prevention and treatment of these disorders it is important to identify both the biological and environmental factors underlying disorder pathogenesis. Several transcriptional changes within the placenta and fetal brain were identified as a result of GDM, MIA, and the combination of the two. Within the placenta, many of these changes were dependent upon the sex of the fetus. |
| 일반주제명 | Immunology. Obstetrics. Cellular biology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
