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The Influence of Inflammation on Sleep, Circadian Functioning, and Risk among Adolescents with an Evening Circadian Preference

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서명/저자사항The Influence of Inflammation on Sleep, Circadian Functioning, and Risk among Adolescents with an Evening Circadian Preference.
개인저자Dolsen, Michael Robert.
단체저자명University of California, Berkeley. Psychology.
발행사항[S.l.]: University of California, Berkeley., 2020.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2020.
형태사항25 p.
기본자료 저록Dissertations Abstracts International 81-04B.
Dissertation Abstract International
ISBN9781085780469
학위논문주기Thesis (Ph.D.)--University of California, Berkeley, 2020.
일반주기 Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Harvey, Allison G.
이용제한사항This item must not be sold to any third party vendors.This item must not be added to any third party search indexes.
요약Background. Adolescence is associated with a shift toward an evening circadian preference, which is linked to increased risk across health domains. This study examined the influence of inflammation on sleep, circadian functioning, and health at pretreatment and following participation in a psychosocial intervention targeting sleep and health.Method. Participants were 165 (96 female, average age = 14.7 years) adolescents randomized to receive 6-sessions of a psychosocial intervention targeting sleep and health. Sleep and circadian outcomes included weeknight total sleep time (TST), weeknight bedtime, and the Children's Morningness-Eveningness Preferences Scale. Health domains included emotional, cognitive, behavioral, social, and physical health. Sleep, circadian, and health outcomes were assessed at pretreatment, posttreatment, 6-month follow-up, and 12-month follow-up. Inflammatory markers were soluble tumor necrosis factor receptor 2 (sTNF-R2), interleukin (IL)-6, and C-reactive protein (CRP) measured at pretreatment.Results. At pretreatment, shorter TST was associated with more emotional domain risk among adolescents with higher CRP. For adolescents with lower IL-6 at pretreatment, a greater evening circadian preference was associated with more behavioral risk. Inflammation also influenced treatment effects. Lower pretreatment sTNF-R2 was related to a decrease in self-reported evening circadian preference following treatment and through follow-up. Lower pretreatment IL-6 was associated with reduced behavioral and physical domain risk following treatment and through follow-up.Conclusions. These findings support a growing body of literature showing that biological factors such as inflammation may influence sensitivity to positive and negative experiences on outcomes across key domains of health during adolescence.
일반주제명Clinical psychology.
Physiology.
Developmental psychology.
Experimental psychology.
Health sciences.
Psychobiology.
Behavioral psychology.
Physiological psychology.
언어영어
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