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Structural Studies on the Regulation of Bacterial Translation
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Structural Studies on the Regulation of Bacterial Translation. |
| 개인저자 | Roy, Raktim. |
| 단체저자명 | Yale University. Chemistry. |
| 발행사항 | [S.l.]: Yale University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 150 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-04B. Dissertation Abstract International |
| ISBN | 9781088315286 |
| 학위논문주기 | Thesis (Ph.D.)--Yale University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Advisor: Steitz, Thomas A. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Antimicrobial peptides are derived from a diverse range of species, from lower eukaryotes to humans, with a mechanism of action that often involves binding the bacterial cell membrane and even disrupting the cell wall. Proline-rich antimicrobial peptides (PrAMPs), however do not act on the cell membrane, but are instead actively transported inside bacteria where they bind and inactivate intra-cellular targets. In this thesis I report the crystal structures of Bac71-35, Pyrrhocoricin, Metalnikowin and Oncocin and two of its derivatives bound to the Thermus thermophilus 70S ribosome. Each of those PrAMPs blocks the peptide exit tunnel of the ribosome and interferes with the initiation step of translation |
| 일반주제명 | Chemistry. Biophysics. Biochemistry. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
