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Mass Spectrometry: An Ideal Method for Rna Modification Analysis
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| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | Mass Spectrometry: An Ideal Method for Rna Modification Analysis. |
| 개인저자 | Wein, Samuel . |
| 단체저자명 | University of Pennsylvania. Biochemistry and Molecular Biophysics. |
| 발행사항 | [S.l.]: University of Pennsylvania., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 101 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-02B. Dissertation Abstract International |
| ISBN | 9781085568968 |
| 학위논문주기 | Thesis (Ph.D.)--University of Pennsylvania, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Advisor: Garcia, Benjamin A. |
| 이용제한사항 | This item must not be sold to any third party vendors. |
| 요약 | Currently there is no good way to measure and find the exact location of multiple RNA modifications. Existing technology can effectively find single varieties of modifications, but cannot identify co-occurrence. As the field of proteomics has shown, mass spectrometry is a powerful and versatile technique assessing broad ranges of chemical modifications in the context of the cellular environment. In this project I used our expertise in proteomics to build a mass spectrometry based platform for identifying RNA modifications. I have since set up both software and analytical platforms querying RNA modifications, and used this platform to survey human tRNA samples and identify what modifications there are, and where they occur. |
| 일반주제명 | Biochemistry. Bioinformatics. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
