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Nucleoid Size Scaling and Intracellular Organization of Translation Across Bacteria

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서명/저자사항Nucleoid Size Scaling and Intracellular Organization of Translation Across Bacteria.
개인저자Gray, William Thomas.
단체저자명Yale University. Pharmacology.
발행사항[S.l.]: Yale University., 2019.
발행사항Ann Arbor: ProQuest Dissertations & Theses, 2019.
형태사항127 p.
기본자료 저록Dissertations Abstracts International 81-03B.
Dissertation Abstract International
ISBN9781085776776
학위논문주기Thesis (Ph.D.)--Yale University, 2019.
일반주기 Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Advisor: Jacobs-Wagner, Christine.
이용제한사항This item must not be sold to any third party vendors.This item must not be added to any third party search indexes.
요약The scaling of organelles with cell size is thought to be exclusive to eukaryotes. Here, we demonstrate that similar scaling relationships hold for the nucleoid in bacteria. Despite the absence of a nuclear membrane, nucleoid size strongly correlates with cell size, independent of changes in DNA amount and across various nutrient conditions. This correlation is observed in diverse bacteria, revealing a near-constant ratio between nucleoid and cell size for a given species. As in eukaryotes, the nucleocytoplasmic ratio in bacteria varies greatly among species. This spectrum of nucleocytoplasmic ratios is independent of genome size, and instead appears linked to the average cell size of the population. Bacteria with different nucleocytoplasmic ratios have different biophysical properties of the cytoplasm, impacting the mobility and localization of ribosomes. Together, our findings identify new organizational principles and biophysical features of bacterial cells, implicating the nucleocytoplasmic ratio and cell size as determinants of the intracellular organization of translation.
일반주제명Microbiology.
Cellular biology.
언어영어
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