상세정보
Export to Refworks부가기능
The Worsening Trajectory of Social Impairment in Preterm Born Young Adults and Its Association with Altered Amygdalar Functional Connectivity
상세 프로파일
| 자료유형 | 학위논문 |
|---|---|
| 서명/저자사항 | The Worsening Trajectory of Social Impairment in Preterm Born Young Adults and Its Association with Altered Amygdalar Functional Connectivity. |
| 개인저자 | Johns, Christina B. |
| 단체저자명 | Yale University. Yale School of Medicine. |
| 발행사항 | [S.l.]: Yale University., 2019. |
| 발행사항 | Ann Arbor: ProQuest Dissertations & Theses, 2019. |
| 형태사항 | 58 p. |
| 기본자료 저록 | Dissertations Abstracts International 81-02B. Dissertation Abstract International |
| ISBN | 9781085592680 |
| 학위논문주기 | Thesis (M.D.)--Yale University, 2019. |
| 일반주기 |
Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Advisor: Ment, Laura R. |
| 이용제한사항 | This item must not be sold to any third party vendors.This item must not be added to any third party search indexes. |
| 요약 | Survivors of preterm birth experience long-lasting behavioral problems characterized by increased risk of depression, anxiety, and impaired social functioning. The amygdala is a key region for social functioning, and alterations in amygdalar structure and connectivity are thought to underlie social functioning deficits in many disorders, including preterm birth. However, the trajectory of social impairments in PT and their association with functional connectivity of the amygdala are not well-studied in former preterm born individuals (PTs). It was hypothesized that PTs would show impaired social functioning compared to term controls beginning in early childhood and continuing to young adulthood. It was also hypothesized that amygdala resting state functional connectivity is altered in PT born young adults, and that alterations in amygdala functional connectivity would mediate increased internalizing behavior and socialization problems in PT born young adults. In a group of former very PT infants (600 to 1250 grams birth weight) and matched term (T) controls, measures of social and emotional behavior were examined using the Child Behavior Checklist (CBCL) administered at ages 8, 12, and 16, the Youth Self Report administered at age 16, and the Vineland Adaptive Behavior Scales (VABS) administered at ages 8 and 18. Amygdalar functional connectivity was examined using resting-state functional magnetic resonance imaging at age 20. By parent report, preterm-born children and adolescents exhibit behaviors demonstrating increased social impairment compared to their term-born peers, starting at school-age and becoming more prominent by young adulthood. PT demonstrate a worsening trajectory in CBCL Withdrawn scores from school-age to young adulthood compared to T (group*time interaction p=0.03), and maternal education has a protective effect on this trajectory in the PT population (withdrawn group*time interaction p=0.01). Furthermore, amygdalar connectivity is altered in the formerly prematurely-born, and markers of social impairment correlate negatively with altered amygdala-posterior cingulate cortex connectivity (Social competence r=-0.37, p=0.03 |
| 일반주제명 | Medicine. Physiology. Developmental psychology. Clinical psychology. Neurosciences. Psychobiology. Social psychology. |
| 언어 | 영어 |
| 바로가기 | 
: 이 자료의 원문은 한국교육학술정보원에서 제공합니다. |
